DHA and elevated blood lipids

A new study Involving hypertriglyceridemic men has found that the fish oil docosahexaenoic acid (DHA) may decrease a specific blood cholesterol (called remnant-like particle-cholesterol (RLP-C) and increase the RBC omega-3 index, thereby improving cardiovascular health.

  • Plasma remnant-like particle-cholesterol (RLP-C) and the RBC (n-3) index are novel risk factors for cardiovascular disease.
  • Hypertriglyceridemic men aged 39-66 years, participated in a randomized, placebo-controlled, parallel study.
  • They received no supplements for 8 days and then received either 7.5 g/d DHA oil (3 g DHA/d) or olive oil (placebo) for the last 90 days.
  • Fasting blood samples were collected on study days: 0 (baseline). 45 (mid-intervention). 84. and 91 (end-intervention).


DHA supplementation for 45 days:

  • Decreased (P < 0.05) fasting RLP-C (36%)
  • Increased plasma eicosapentaenoic acid (EPA):arachidonic acid (AA) (100%)
  • Improved the RBC (n-3) index (109%)

Continued supplementation with DHA between d 45 and 91 further increased the RBC (n-3) index (162%) and Plasma EPA:AA (137%) compared with baseline values.

Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases the (n-3) index in hypertriglyceridemic men' Kelley DS, Siegel D. et al. J Nutr. 2008: 138(1): 30-5.

Green tea: fat burning and glycaemic control

More good news about green tea and weightloss. Two new studies suggest that green tea extract acts in 3 ways: Green tea improves insulin sensitivity. lipolysis (fat burning) and glycaemic control.

The first study found that green tea extract improved the fat burning (fat oxidation) by 17% in healthy Young men who took 3 capsules containing a total of 890 mg polyphenols and 366 mg EGCG.

In the second study, green tea extract was found to improve insulin resistance by 13% in the glucose tolerance test in healthy men.

The authors conclude that, "...Acute ingestion of green tea can increase fat oxidation during moderate-intensity exercise, possibly through an increase in lipolysis and therefore an increased availability of fat as a fuel. Green tea ingestion can also improve glycemic control after an oral glucose load and could have the potential to reduce the risk of type 2 diabetes mellitus."

Reference: Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Venables MC, Hulston CJ, et al. Am j Clin Nutr, 2008: 87(3): 778-84  Abstract BACKGROUND: Green tea consumption is reportedly associated with various health-promoting properties. For example, it has been shown to promote fat oxidation in humans at rest and to prevent obesity and improve insulin sensitivity in mice.

OBJECTIVE: We investigated the effects of acute ingestion of green tea extract (GTE) on glucose tolerance and fat oxidation during moderate-intensity exercise in humans.

DESIGN: Two studies were performed, both with a counter-balanced crossover design.
In study A. 12 healthy men performed a 30-min cycling exercise at 60% of maximal oxygen consumption (V02max) before and after supplementation. In study B. 11 healthy men took an oral-glucose-tolerance test before and after supplementation. In the 24-h period before the experimental trials, participants ingested 3 capsules containing either GTE (total: 890 +/- 13mg polyphenols and 366+/- 5 mg EGCG) or a corn-flour placebo (total: 1729 +/- 22 mg).
RESULTS: Average fat oxidation rates were 17% higher after ingestion of GTE than after ingestion of placebo (0.41 +/- 0.03 and 0.35 +/- 0.03 g/min, respectively: P <0.05).
Moreover, the contribution of fat oxidation to total energy expenditure was also significantly higher by a similar percentage after GTE supplementation. The insulin area under the curve decreased in both the GTE and placebo trials (3612 +/- 301 and 4280 ,+/- 309 microlU/dL . 120 min. respectively,  P<0.01), and there was a concomitant increase of 13% in insulin sensitivity.
CONCLUSIONS: Acute GTE ingestion can increase fat oxidation during moderate-intensity exercise and can improve insulin sensitivity and glucose tolerance in healthy young men.

Vitamin E improves immunity in the elderly

A new study suggests that supplementation with vitamin E may improve the immune defense in the elderly. Healthy elderly men and women were supplemented with 200 mg per day for 3 months. Compared to non-elderly healthy adults (the controls), the elderly adults were found to have impaired immunity characterized by less than optimal neutrophils, lymphocytes and natural killer cells.

After supplementations the immune system functioned almost as good in the elderly as in the non-elderly adults. On re-testing six months later, some of the positive benefits were still present in spite of have taken no vitamin E for six month.

The authors of the study concluded that: "The present findings suggest that supplementation with vitamin E can produce an improvement of immune functions and therefore of health in aged people."

Vitamin E can be given in tablet or capsules or even in powders. Sphere Healthcare has several different types of vitamin E available for various applications and product types.

Reference: Vitamin E ingestion improves several immune functions in elderly men and women. De la Fuente M. Hernanz A. et al. Free Radic Res, 2008: 42(3): 272-80.